ABSTRACT
Acute Promyelositik Leukemia (APL) is a rare form of leukemia acute myeloid series. APL is
to be distinguished from acute myelositik leukemia (AML) subtype because of the
risk of disseminated intravascular coagulation (DIC) and response to therapy of
AML. APL cases obtained only 10-15% of AML in adults, approximately 15% -25% of
cases of APL include microgranular variant (M3V), which is characterized by
promyelosit with little or no granular and rare Auer rods. Clinical symptoms of
APL cases, often associated with bleeding manifestations and risk of
coagulopathy. 50-year-old woman reportedly came up with gingival bleeding and fatigue for about a month. On
examination of peripheral blood obtained Hb 7.7 mg/dl, leucocytes 37.100/µl,
platelets 23.000/µl with promyelosit 93%. In the bone marrow aspirate was found
hiperseluler, and dominated by promyelosit cells (96%) with "dumb-bell
shaped", slightly granular and no Auer rods obtained. In these patients
recommended for examination immunophenotyping as further investigation.
Key words: APL; AML; microgranular variant;
dumb-bell shaped
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